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hPBMC-B Cell Reconstitution Model
hPBMC-B Cell Reconstitution Model, a pioneering technology developed by Creative Bioarray, represents a groundbreaking humanized mouse model tailored for the rigorous pre-clinical assessment of tumor immunotherapies and drugs targeting autoimmune disorders. This model revolutionizes the landscape of immunological research by addressing the inherent constraints of conventional PBMC (Peripheral Blood Mononuclear Cell) and CD34+ HSC (Hematopoietic Stem Cell) models, which fall short in replicating the critical role of human antibodies in mediating immune responses.
Features and Advantages
- Successful reconstitution of human B-cells in immunodeficient mice: Facilitating a realistic mimicry of human immune responses.
- Enhanced antibody secretion capability: Our reconstructed B cells possess antibody secretion functionality, providing richer data for research.
- Complete humoral immunity process: This model comprehensively recapitulates the entire humoral immune cascade, encompassing antigen presentation, B-cell activation, and subsequent antibody production, offering a holistic understanding of the process.
- Versatile research platform: Suitable for foundational research endeavors and drug discovery initiatives across diverse biomedical fields, including autoimmune disorders, tumor immunology, and viral immunology.
Applications
- Evaluation of immunotherapy efficacy: Accurately evaluating the therapeutic outcomes and safety profiles of tumor immunotherapies within a genuine humanized immune microenvironment.
- Exploration of autoimmune disease mechanisms: Providing profound insights into the underlying pathogenesis of autoimmune diseases, thereby guiding the strategic development of novel therapeutic agents.
- Evaluation of viral immune responses: Comprehensively assessing the immunomodulatory effects of diverse viral pathogens on the human immune system, informing the rational design of vaccines and antiviral therapeutics.
Example Data
Fig. 1 B cell reconstitution.
Fig. 2 Human IgG levels in mouse plasma after PBMC injection.
Quotation and Ordering
Leveraging our team's deep expertise in humanized mouse models and an advanced research platform, Creative Bioarray is well-equipped to offer tailored pharmacology services for immunotherapy research. We craft personalized solutions and analysis workflows to meet your specific scientific needs, ensuring real-time project monitoring to expedite your research breakthroughs. Interested in our services? Please feel free to contact us at any time or directly submit an inquiry.
For research use only. Not for any other purpose.
