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Ballon Injury and High-Fat Diet-Induced Atherosclerosis Model
Creative Bioarray is proud to present a diverse portfolio of atherosclerosis models, meticulously designed for the screening, testing, and evaluation of emerging drugs and formulations. Our innovative approach is highlighted by a unique model that combines balloon injury with a high-fat diet to induce atherosclerosis in rats effectively. We invite you to explore our capabilities further and discover how we can be your partner in unlocking the next breakthrough in atherosclerosis therapy.
Balloon injury surgery is a widely used method for creating models of restenosis after vascular injury. The procedure involves inserting a balloon with a specific diameter into the arterial vasculature and then inflating it. This causes damage to the endothelial cells lining the arterial walls, as the inflated balloon is repeatedly dragged and pulled. Consequently, the endothelial cells detach immediately, leading to severe impairment of the elastic lamina and the medial layer, as well as localized stenosis of the vasculature.
Building on this foundation, we have developed the Balloon Injury and High-Fat Diet-Induced Atherosclerosis Model. This model combines the endothelial damage caused by balloon injury with the administration of a high-fat diet to rats. This model accurately simulates atherosclerosis and provides a controlled environment for evaluating new therapeutic interventions. It is a crucial tool for advancing cardiovascular disease research and the development of treatment.
Our Ballon Injury and High-Fat Diet-Induced Atherosclerosis Model
- Available Animal
- Rat
- New Zealand white rabbit
- Modeling Method
At Creative Bioarray, we induce an atherosclerosis model by using a high-fat diet combined with balloon injury. This method leverages the synergistic effects of a diet rich in fats and the mechanical disruption caused by balloon injury to accelerate the development of atherosclerotic lesions in animal models. The high-fat diet contributes to the dysregulation of lipid metabolism, while the balloon injury introduces endothelial damage, both of which are critical factors in the pathogenesis of atherosclerosis.
- Endpoints
- Atherosclerotic plaques observation
- Serum analysis: TG, TC, HDL-c, LDL-c
- Histology analysis: H&E staining, Oil red O staining
- qPCR or Western Blot
- Body weight
- Other customized endpoints
Quotation and Ordering
Creative Bioarray assists clients in selecting the most validated and reliable models for evaluating their compounds, ensuring the acquisition of clinically relevant data. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
For research use only. Not for any other purpose.
