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PAX5 FISH Probe
- Specification
Cat.No.
FONC-152
Description
PAX5 FISH Probe is expertly designed to detect amplifications and deletions of the PAX5 gene, a critical regulator in B-cell development. This probe comes in a vibrant orange color for optimal visualization, and customization options are available to meet your specific research needs.
PAX5 plays a pivotal role in the differentiation of B-cells, overseeing their development from the pro-B to the mature B cell stage, ultimately guiding their terminal differentiation into plasma cells. Abnormalities in PAX5, particularly translocations, can result in the formation of fusion genes that encode chimeric proteins with altered PAX5 functionality. These aberrations occur in 2–3% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, highlighting the gene's significance in leukemia pathology.
PAX5 is known to be a promiscuous fusion partner, with over 16 different partner genes identified in association with leukemia-related fusions. This flexibility in forming fusion genes is indicative of PAX5's central role in the intricate network of genetic alterations that contribute to the development of various hematological malignancies. The identification of PAX5 alterations is critical for diagnosis, prognosis, and the formulation of treatment strategies.
Utilizing our PAX5 FISH Probe enables researchers to enhance their understanding of these genetic changes, facilitating accurate detection of PAX5 amplifications and deletions.
PAX5 plays a pivotal role in the differentiation of B-cells, overseeing their development from the pro-B to the mature B cell stage, ultimately guiding their terminal differentiation into plasma cells. Abnormalities in PAX5, particularly translocations, can result in the formation of fusion genes that encode chimeric proteins with altered PAX5 functionality. These aberrations occur in 2–3% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases, highlighting the gene's significance in leukemia pathology.
PAX5 is known to be a promiscuous fusion partner, with over 16 different partner genes identified in association with leukemia-related fusions. This flexibility in forming fusion genes is indicative of PAX5's central role in the intricate network of genetic alterations that contribute to the development of various hematological malignancies. The identification of PAX5 alterations is critical for diagnosis, prognosis, and the formulation of treatment strategies.
Utilizing our PAX5 FISH Probe enables researchers to enhance their understanding of these genetic changes, facilitating accurate detection of PAX5 amplifications and deletions.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
9p13.2
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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