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PAX3 FISH Probe
- Specification
Cat.No.
FONC-139
Description
PAX3 FISH Probe is specifically designed to detect amplifications and deletions of the PAX3 gene. This probe comes labeled in vibrant orange for optimal visualization, and we offer customization options to meet your specific research needs.
The PAX3 (Paired Box 3) gene encodes a transcription factor that plays a critical role in embryonic development, particularly in the formation of neural crest cells and skeletal muscles. It is involved in various developmental processes and is essential for proper cell differentiation and proliferation. Alterations in PAX3, including amplifications and deletions, have been linked to several malignancies, notably alveolar rhabdomyosarcoma and other soft tissue tumors.
Clinical Relevance: Detecting PAX3 amplifications and deletions is crucial for accurately diagnosing and characterizing tumors in which PAX3 plays a pivotal role. In alveolar rhabdomyosarcoma, for example, PAX3 dysregulation contributes to the oncogenic process, leading to aggressive tumor behavior and poor prognosis. Identifying these genetic alterations can provide significant insights into the biology of the tumor and its potential responsiveness to therapy.
Understanding the status of PAX3 in tumors can guide treatment decisions and inform the development of targeted therapies aimed at restoring normal PAX3 function or inhibiting its effects in cancers where it acts as an oncogene.
Our PAX3 FISH Probe is an invaluable tool for researchers focused on exploring the role of PAX3 in tumorigenesis and advancing precision medicine approaches in oncology.
The PAX3 (Paired Box 3) gene encodes a transcription factor that plays a critical role in embryonic development, particularly in the formation of neural crest cells and skeletal muscles. It is involved in various developmental processes and is essential for proper cell differentiation and proliferation. Alterations in PAX3, including amplifications and deletions, have been linked to several malignancies, notably alveolar rhabdomyosarcoma and other soft tissue tumors.
Clinical Relevance: Detecting PAX3 amplifications and deletions is crucial for accurately diagnosing and characterizing tumors in which PAX3 plays a pivotal role. In alveolar rhabdomyosarcoma, for example, PAX3 dysregulation contributes to the oncogenic process, leading to aggressive tumor behavior and poor prognosis. Identifying these genetic alterations can provide significant insights into the biology of the tumor and its potential responsiveness to therapy.
Understanding the status of PAX3 in tumors can guide treatment decisions and inform the development of targeted therapies aimed at restoring normal PAX3 function or inhibiting its effects in cancers where it acts as an oncogene.
Our PAX3 FISH Probe is an invaluable tool for researchers focused on exploring the role of PAX3 in tumorigenesis and advancing precision medicine approaches in oncology.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
2q36.1
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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