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NFKB2 Break Apart FISH Probe
- Specification
Cat.No.
FONC-137
Description
NFKB2 Break Apart FISH Probe is specifically designed to detect translocations involving the NFKB2 gene. This probe features vibrant green and orange labeling for clear visualization, and we offer customization options to meet your specific research requirements.
The NFKB2 (Nuclear Factor Kappa B Subunit 2) gene encodes a protein that is a critical component of the NF-κB signaling pathway, which regulates various cellular processes, including immune response, inflammation, and cell survival. NFKB2 plays a significant role in the development and function of immune cells, and its dysregulation has been implicated in various hematological malignancies, particularly lymphomas and leukemias.
Translocations involving NFKB2 can lead to aberrant expression and activity of NF-κB, contributing to oncogenesis by promoting cell proliferation and inhibiting apoptosis. These genetic alterations are often associated with aggressive forms of cancer, including certain types of diffuse large B-cell lymphoma (DLBCL) and other lymphoproliferative disorders.
Clinical Relevance: Detecting NFKB2 translocations is essential for the accurate diagnosis and classification of lymphomas and leukemias. Identifying these genetic alterations can provide valuable insights into disease prognosis and may inform targeted therapeutic strategies. The presence of NFKB2 translocations can influence treatment decisions and help guide personalized medicine approaches for patients with hematological malignancies.
Our NFKB2 Break Apart FISH Probe is an invaluable tool for researchers dedicated to understanding the role of NFKB2 in cancer biology and advancing targeted therapies for patients with translocation-associated malignancies.
The NFKB2 (Nuclear Factor Kappa B Subunit 2) gene encodes a protein that is a critical component of the NF-κB signaling pathway, which regulates various cellular processes, including immune response, inflammation, and cell survival. NFKB2 plays a significant role in the development and function of immune cells, and its dysregulation has been implicated in various hematological malignancies, particularly lymphomas and leukemias.
Translocations involving NFKB2 can lead to aberrant expression and activity of NF-κB, contributing to oncogenesis by promoting cell proliferation and inhibiting apoptosis. These genetic alterations are often associated with aggressive forms of cancer, including certain types of diffuse large B-cell lymphoma (DLBCL) and other lymphoproliferative disorders.
Clinical Relevance: Detecting NFKB2 translocations is essential for the accurate diagnosis and classification of lymphomas and leukemias. Identifying these genetic alterations can provide valuable insights into disease prognosis and may inform targeted therapeutic strategies. The presence of NFKB2 translocations can influence treatment decisions and help guide personalized medicine approaches for patients with hematological malignancies.
Our NFKB2 Break Apart FISH Probe is an invaluable tool for researchers dedicated to understanding the role of NFKB2 in cancer biology and advancing targeted therapies for patients with translocation-associated malignancies.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Specificity
Human
Locus
10q20.3
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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