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MECOM Tri-Color Break Apart FISH Probe
- Specification
Cat.No.
FONC-121
Description
MECOM Tri-Color Break Apart FISH Probe is expertly designed to detect MECOM translocations, enhancing the detection of genetic abnormalities. This probe features vibrant labeling in orange, green, and aqua for clear differentiation, with options for customization to align with your specific research requirements.
MECOM (MDS1 and EVI1 complex locus) encodes a zinc finger protein serving as a key transcriptional regulator. Abnormal expression of MECOM commonly arises from its structural rearrangements, with the most prevalent being inv(3)(q21;q26.2) and t(3;21)(q36.2;q22). The breakpoints involved in these rearrangements can vary significantly. MECOM is frequently mutated in hematological malignancies of myeloid origin, such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Notably, AML associated with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) is recognized by the World Health Organization (WHO) as a distinct disease entity, marked by abnormalities in MECOM at 3q26.2 and RPN1 (ribophorin I) at 3q21.2. Additionally, MECOM has been implicated in therapy-related malignancies through t(3;21)(q26.2;q22), leading to fusion with RUNX1.
MECOM (MDS1 and EVI1 complex locus) encodes a zinc finger protein serving as a key transcriptional regulator. Abnormal expression of MECOM commonly arises from its structural rearrangements, with the most prevalent being inv(3)(q21;q26.2) and t(3;21)(q36.2;q22). The breakpoints involved in these rearrangements can vary significantly. MECOM is frequently mutated in hematological malignancies of myeloid origin, such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Notably, AML associated with inv(3)(q21q26.2) or t(3;3)(q21;q26.2) is recognized by the World Health Organization (WHO) as a distinct disease entity, marked by abnormalities in MECOM at 3q26.2 and RPN1 (ribophorin I) at 3q21.2. Additionally, MECOM has been implicated in therapy-related malignancies through t(3;21)(q26.2;q22), leading to fusion with RUNX1.
Size
10 Tests; 20 Tests
Label
Red/Green/Aqua
Locus
3q26.2
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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