MAF-IGH Full FISH Probe

FONC-147

MAF-IGH Full FISH Probe is specifically designed to detect fusions between the IGH (Immunoglobulin Heavy Chain) locus and the MAF gene. This full probe provides comprehensive coverage of the entire MAF gene, ensuring accurate detection of genetic rearrangements. The probe is labeled in vibrant orange and green for optimal visualization, and we offer customization options to meet your specific research needs.

The IGH locus is crucial for the production of immunoglobulins, playing a significant role in the immune response. The MAF gene encodes a transcription factor involved in regulating gene expression during development and differentiation. Fusions between IGH and MAF have been associated with various hematological malignancies, particularly multiple myeloma and certain types of lymphoma. These fusions can lead to dysregulation of oncogenes, contributing to tumorigenesis.

Clinical Relevance: Detecting IGH/MAF fusions is essential for understanding the molecular mechanisms underlying these malignancies. The presence of such fusions can indicate a more aggressive disease phenotype and may influence treatment decisions. Identifying these genetic alterations can help guide targeted therapies, improving patient outcomes and informing prognosis.

Our IGH/MAF Full FISH Probe is an invaluable tool for researchers dedicated to advancing the understanding of genetic alterations in hematological cancers.

10 Tests; 20 Tests

Orange/Green/Aqua

Human

14q32.33/16q23.2

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade in the dark

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.