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Immortalized Human Ovarian Epithelial Cells-SV40
Cat.No.: CSC-I9009L
Species: homo sapiens
Source: Ovaries
Morphology: Polygonal (at low density), Cuboidal (at high density)
Culture Properties: Adherent
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Note: Never can cells be kept at -20 °C.
CIK-HT003 HT® Lenti-SV40T Immortalization Kit
Primary cells reach a state of replicative senescence after a certain amount of proliferation, and a certain number of divisions, thus limiting the proliferation of senescent or damaged cells. GeneCopoeia provides cell immortalization reagents that induce immortalization using recombinant lentiviral-carrying genes, such as simian virus 40 (SV40) large T-antigen and human telomerase reverse transcriptase protein (hTERT), can significantly extend the lifespan of primary cells.
Immortalized Human Ovarian Epithelial Cells-SV40 are ovarian epithelial cells that have been transformed using the SV40 large T antigen, allowing them to proliferate while retaining key characteristics of normal ovarian epithelial cells. These models are essential for studying ovarian biology and related diseases.
These cells are widely applicable and can be used in various research fields, including:
Ovarian cancer research and drug response studies.
Investigating ovarian physiology and hormone regulation.
Studies on cell signaling pathways in ovarian cells.
Research on epithelial-to-mesenchymal transition (EMT) in cancer.
Toxicology assessments regarding ovarian toxicity.
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Average Rating: 5.0 | 1 Scientist has reviewed this product
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09 Oct 2022
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Description: Microglia cells are resident macrophages of the brain and spinal cord and they act as the first and the main form of active immune defense in the nervous system. The Immortalized Human Microglia - SV40 cell line is derived from Primary Human Microglia Cells (>99% purity) and have maintained microglial marker TREM2 as demonstrated by RT-PCR. These cells are suitable for studies of human microglia in health and disease.
Description: Immortalized Human Umbilical Vein Endothelial Cells-hTERT were developed from human tissues transduced with a lentiviral expression vector containing the hTERT gene. The cell line was continuously cultured for more than 20 passages without showing signs of growth retardation or replicative senescence. The Immortalized Human Umbilical Vein Endothelial Cells are useful for setting up in vitro bioassays for studying angiogenesis in e.g. wound healing or metastasis as well as bioassays for testing the angiogenic properties of novel drugs. Additionally, the cell line is the perfect starting material for genetic engineering to create important disease models.
