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IGH-BCL2 Full Fusion FISH Probe
- Specification
Cat.No.
FONC-136
Description
IGH/BCL2 Full Fusion FISH Probe is expertly designed to detect fusions between the IGH and BCL2 genes. This probe features vibrant green and orange labeling for optimal visualization and can be customized to meet your specific research needs.
The IGH (Immunoglobulin Heavy Chain) gene is located on chromosome 14 and plays a crucial role in the immune response by encoding the heavy chain of immunoglobulins. The BCL2 (B-cell lymphoma 2) gene, located on chromosome 18, encodes a protein that regulates cell death (apoptosis) and is known for its role in promoting cell survival. The fusion of IGH and BCL2 is commonly associated with follicular lymphoma and other B-cell malignancies, resulting from the chromosomal translocation t(14;18)(q32;q21). This fusion leads to the overexpression of the BCL2 protein, contributing to the pathogenesis of these lymphomas by inhibiting apoptosis and allowing malignant B-cells to survive longer than normal.
Clinical Relevance: Detecting IGH/BCL2 fusions is essential for the diagnosis and classification of follicular lymphoma and other related lymphoproliferative disorders. The presence of this genetic alteration can provide valuable insights into disease prognosis and may inform treatment strategies. Understanding the role of the IGH/BCL2 fusion in tumor biology is critical for developing targeted therapies aimed at restoring normal apoptotic processes in affected cells.
It is important to note that the region in which the IGH gene lies is known for high levels of cross-homology with other genomic regions. This homology can lead to diffuse probe signals, which may affect the clarity of results. Careful interpretation of FISH results is recommended to ensure accurate diagnosis.
Our IGH/BCL2 Full Fusion FISH Probe is an invaluable tool for researchers dedicated to exploring the complexities of B-cell malignancies and advancing personalized treatment approaches.
The IGH (Immunoglobulin Heavy Chain) gene is located on chromosome 14 and plays a crucial role in the immune response by encoding the heavy chain of immunoglobulins. The BCL2 (B-cell lymphoma 2) gene, located on chromosome 18, encodes a protein that regulates cell death (apoptosis) and is known for its role in promoting cell survival. The fusion of IGH and BCL2 is commonly associated with follicular lymphoma and other B-cell malignancies, resulting from the chromosomal translocation t(14;18)(q32;q21). This fusion leads to the overexpression of the BCL2 protein, contributing to the pathogenesis of these lymphomas by inhibiting apoptosis and allowing malignant B-cells to survive longer than normal.
Clinical Relevance: Detecting IGH/BCL2 fusions is essential for the diagnosis and classification of follicular lymphoma and other related lymphoproliferative disorders. The presence of this genetic alteration can provide valuable insights into disease prognosis and may inform treatment strategies. Understanding the role of the IGH/BCL2 fusion in tumor biology is critical for developing targeted therapies aimed at restoring normal apoptotic processes in affected cells.
It is important to note that the region in which the IGH gene lies is known for high levels of cross-homology with other genomic regions. This homology can lead to diffuse probe signals, which may affect the clarity of results. Careful interpretation of FISH results is recommended to ensure accurate diagnosis.
Our IGH/BCL2 Full Fusion FISH Probe is an invaluable tool for researchers dedicated to exploring the complexities of B-cell malignancies and advancing personalized treatment approaches.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Specificity
Human
Locus
14q32.33/18q21.33
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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