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Human iPSC-derived Brain Microvascular Endothelial Cells
- Specification
Cat.No.
CSC-00892L
Description
Blood Brain Barrier (BBB) is an important feature of the cerebral vasculature. Cells that form the barrier are called Brain Microvascular Endothelial Cells (BMECs). The barrier regulates the transport of molecular chemicals (including metabolites) and cells between the brain and blood. The barrier’s functionality is conducted via specialized groups of tight junction proteins and transporters. Found in diseases like Multiple Sclerosis, Alzheimer’s, Parkinson’s, Epilepsy, and stroke, the delicate balance between brain and blood is perturbed and BBB dysfunction can play a significant role in the disease progression.
Human iPSC-derived Brain Microvascular Endothelial Cells (iBMECs) are derived from integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction condition. iBMEC cells are compact cellular structures when plated as a monolayer in culture and express standard biomarkers such as ECadherin and ZO-1 using immunohistochemistry methods and transporter biomarkers such as ABCB1 (P-gp), ABCG2, ABCE1, HIF1A, CLDN5, GLUT1, LAT1, MCT1, TJP1, PDGFbeta, OCLN, SLC25A3, TFR1, and SLC25A5 using RT/qPCR methods.
Human iPSC-derived Brain Microvascular Endothelial Cells (iBMECs) are derived from integration-free induced pluripotent stem cell (iPSC) lines under a fully defined proprietary induction condition. iBMEC cells are compact cellular structures when plated as a monolayer in culture and express standard biomarkers such as ECadherin and ZO-1 using immunohistochemistry methods and transporter biomarkers such as ABCB1 (P-gp), ABCG2, ABCE1, HIF1A, CLDN5, GLUT1, LAT1, MCT1, TJP1, PDGFbeta, OCLN, SLC25A3, TFR1, and SLC25A5 using RT/qPCR methods.
Species
Human
Applications
For Research Use Only
Shipping
Dry Ice
Quality Control
Sterility, Safety, HIV/viruses, bacteria, fungi: negative.
Storage and Shipping
remove cryovials (dry ice packaging) and place the vial into liquid nitrogen for storage. Alternatively, thaw and use the cells immediately.
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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