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HMGA2 FISH Probe
- Specification
Cat.No.
FONC-131
Description
HMGA2 FISH Probe is specifically designed to detect amplifications and deletions of the HMGA2 gene. This probe is available with vibrant orange labeling for enhanced visualization, and we offer customization options to meet your specific research requirements.
HMGA2 (High Mobility Group AT-Hook 2) is a non-histone chromatin-binding protein that plays a significant role in regulating gene expression and chromatin structure. It is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. Aberrant expression of HMGA2 has been linked to several types of tumors, including liposarcoma, thyroid cancer, and various other malignancies. Amplifications of the HMGA2 gene can lead to its overexpression, contributing to oncogenic processes and tumor progression.
Clinical Relevance: The detection of HMGA2 amplifications and deletions is crucial for understanding the molecular mechanisms underlying these cancers. Identifying these genetic alterations can provide insights into tumor behavior and potential therapeutic targets. Furthermore, HMGA2 has been associated with poor prognosis in certain cancers, making it a valuable biomarker for risk assessment and treatment planning.
Our HMGA2 FISH Probe is an essential tool for researchers dedicated to exploring the role of HMGA2 in cancer biology and advancing personalized treatment strategies.
HMGA2 (High Mobility Group AT-Hook 2) is a non-histone chromatin-binding protein that plays a significant role in regulating gene expression and chromatin structure. It is involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. Aberrant expression of HMGA2 has been linked to several types of tumors, including liposarcoma, thyroid cancer, and various other malignancies. Amplifications of the HMGA2 gene can lead to its overexpression, contributing to oncogenic processes and tumor progression.
Clinical Relevance: The detection of HMGA2 amplifications and deletions is crucial for understanding the molecular mechanisms underlying these cancers. Identifying these genetic alterations can provide insights into tumor behavior and potential therapeutic targets. Furthermore, HMGA2 has been associated with poor prognosis in certain cancers, making it a valuable biomarker for risk assessment and treatment planning.
Our HMGA2 FISH Probe is an essential tool for researchers dedicated to exploring the role of HMGA2 in cancer biology and advancing personalized treatment strategies.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
12q14.3
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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