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ETV6/NTRK3 Fusion FISH Probe
- Specification
Cat.No.
FONC-129
Description
ETV6/NTRK3 Fusion FISH Probe is expertly designed to detect fusions between the ETV6 and NTRK3 genes. This probe is available with vibrant green and orange labeling for clear visualization, and we offer customization options to meet your specific research requirements.
The ETV6 (ETS Variant 6) gene is a transcription factor that regulates various processes, including hematopoiesis and cell differentiation. The NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) gene is essential for neuronal survival and development. Fusions involving ETV6 and NTRK3 are primarily associated with certain pediatric and adult cancers, including congenital fibrosarcoma and various types of sarcomas. These fusions result in the creation of a hybrid oncogene that can lead to abnormal signaling pathways, promoting cell proliferation and survival.
Clinical Relevance: Detecting ETV6/NTRK3 fusions is crucial for the accurate diagnosis and prognosis of tumors characterized by this genetic alteration. The presence of this fusion can help guide tailored therapeutic approaches, as tumors harboring NTRK fusions may be sensitive to targeted therapies, such as TRK inhibitors. Identifying ETV6/NTRK3 fusions opens avenues for precision medicine, allowing for more effective treatment options for affected patients.
Our ETV6/NTRK3 Fusion FISH Probe is an invaluable tool for researchers dedicated to uncovering the complexities of oncogenic fusions and advancing targeted cancer therapies.
The ETV6 (ETS Variant 6) gene is a transcription factor that regulates various processes, including hematopoiesis and cell differentiation. The NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) gene is essential for neuronal survival and development. Fusions involving ETV6 and NTRK3 are primarily associated with certain pediatric and adult cancers, including congenital fibrosarcoma and various types of sarcomas. These fusions result in the creation of a hybrid oncogene that can lead to abnormal signaling pathways, promoting cell proliferation and survival.
Clinical Relevance: Detecting ETV6/NTRK3 fusions is crucial for the accurate diagnosis and prognosis of tumors characterized by this genetic alteration. The presence of this fusion can help guide tailored therapeutic approaches, as tumors harboring NTRK fusions may be sensitive to targeted therapies, such as TRK inhibitors. Identifying ETV6/NTRK3 fusions opens avenues for precision medicine, allowing for more effective treatment options for affected patients.
Our ETV6/NTRK3 Fusion FISH Probe is an invaluable tool for researchers dedicated to uncovering the complexities of oncogenic fusions and advancing targeted cancer therapies.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
15q25.3
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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