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CD74/ROS1 FISH Probe
- Specification
Cat.No.
FONC-132
Description
CD74/ROS1 Fusion FISH Probe is expertly designed to detect fusions between the CD74 and ROS1 genes. This probe features vibrant green and orange labeling for clear visualization, and we offer customization options to meet your specific research requirements.
The CD74 gene encodes a protein that serves as a receptor for the cytokine macrophage migration inhibitory factor (MIF) and plays a crucial role in immune response and antigen presentation. The ROS1 gene encodes a receptor tyrosine kinase involved in cell signaling pathways that regulate cell growth and differentiation. Fusions involving CD74 and ROS1 are primarily associated with certain types of cancers, particularly non-small cell lung cancer (NSCLC) and some hematological malignancies. These fusions result in the formation of a hybrid oncogene that can drive tumorigenesis through aberrant signaling pathways.
Clinical Relevance: Detecting CD74/ROS1 fusions is essential for the accurate diagnosis and prognosis of tumors characterized by this genetic alteration. The presence of this fusion can guide targeted therapeutic approaches, as tumors harboring ROS1 fusions may respond well to specific inhibitors, such as crizotinib and entrectinib. Identifying CD74/ROS1 fusions not only aids in treatment decision-making but also enhances our understanding of the molecular mechanisms underlying these cancers.
Our CD74/ROS1 Fusion FISH Probe is an invaluable tool for researchers dedicated to uncovering the complexities of oncogenic fusions and advancing targeted cancer therapies.
The CD74 gene encodes a protein that serves as a receptor for the cytokine macrophage migration inhibitory factor (MIF) and plays a crucial role in immune response and antigen presentation. The ROS1 gene encodes a receptor tyrosine kinase involved in cell signaling pathways that regulate cell growth and differentiation. Fusions involving CD74 and ROS1 are primarily associated with certain types of cancers, particularly non-small cell lung cancer (NSCLC) and some hematological malignancies. These fusions result in the formation of a hybrid oncogene that can drive tumorigenesis through aberrant signaling pathways.
Clinical Relevance: Detecting CD74/ROS1 fusions is essential for the accurate diagnosis and prognosis of tumors characterized by this genetic alteration. The presence of this fusion can guide targeted therapeutic approaches, as tumors harboring ROS1 fusions may respond well to specific inhibitors, such as crizotinib and entrectinib. Identifying CD74/ROS1 fusions not only aids in treatment decision-making but also enhances our understanding of the molecular mechanisms underlying these cancers.
Our CD74/ROS1 Fusion FISH Probe is an invaluable tool for researchers dedicated to uncovering the complexities of oncogenic fusions and advancing targeted cancer therapies.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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