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CCNE1/CEN 19 FISH Probe
- Specification
Cat.No.
FONC-143
Description
CCNE1/CEN 19 FISH Probe is expertly designed to detect amplifications and deletions of the CCNE1 gene, providing critical insights into its role in various malignancies. This probe is labeled in vibrant orange and green for optimal visualization, and we offer customization options to meet your specific research requirements.
The CCNE1 (Cyclin E1) gene encodes a regulatory protein that is essential for cell cycle progression, particularly the transition from the G1 phase to the S phase. Dysregulation of CCNE1, often through gene amplifications, has been implicated in several cancers, including breast, ovarian, and endometrial cancers. Overexpression of CCNE1 can lead to uncontrolled cell proliferation and contribute to tumorigenesis.
Clinical Relevance: Detecting CCNE1 amplifications and deletions is crucial for the diagnosis and characterization of tumors where CCNE1 plays a significant role. The presence of CCNE1 amplifications is often associated with poor prognosis and aggressive tumor behavior, making it an important biomarker for treatment decisions. Understanding the status of CCNE1 can inform targeted therapeutic strategies, including the use of CDK inhibitors, which may be effective in tumors exhibiting CCNE1 dysregulation.
Our CCNE1/CEN 19 FISH Probe is an invaluable tool for researchers and clinicians dedicated to advancing the understanding of CCNE1 in cancer biology. By utilizing this probe, you can enhance your ability to identify genetic alterations that may impact patient management and treatment outcomes.
With our customizable options, the CCNE1/Control 19 FISH Probe is designed to meet the diverse needs of your research applications, facilitating the exploration of CCNE1's role in oncogenesis and improving patient care.
The CCNE1 (Cyclin E1) gene encodes a regulatory protein that is essential for cell cycle progression, particularly the transition from the G1 phase to the S phase. Dysregulation of CCNE1, often through gene amplifications, has been implicated in several cancers, including breast, ovarian, and endometrial cancers. Overexpression of CCNE1 can lead to uncontrolled cell proliferation and contribute to tumorigenesis.
Clinical Relevance: Detecting CCNE1 amplifications and deletions is crucial for the diagnosis and characterization of tumors where CCNE1 plays a significant role. The presence of CCNE1 amplifications is often associated with poor prognosis and aggressive tumor behavior, making it an important biomarker for treatment decisions. Understanding the status of CCNE1 can inform targeted therapeutic strategies, including the use of CDK inhibitors, which may be effective in tumors exhibiting CCNE1 dysregulation.
Our CCNE1/CEN 19 FISH Probe is an invaluable tool for researchers and clinicians dedicated to advancing the understanding of CCNE1 in cancer biology. By utilizing this probe, you can enhance your ability to identify genetic alterations that may impact patient management and treatment outcomes.
With our customizable options, the CCNE1/Control 19 FISH Probe is designed to meet the diverse needs of your research applications, facilitating the exploration of CCNE1's role in oncogenesis and improving patient care.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
19q21/19p13.11
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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