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CCND1-IGH Full Fusion FISH Probe
- Specification
Cat.No.
FONC-134
Description
CCND1/IGH Full Fusion FISH Probe is specifically designed to detect fusions between the CCND1 and IGH genes. Unlike our split CCND1/IGH probe, this full probe covers the entire IGH gene for enhanced sensitivity and specificity.
The CCND1/IGH fusion results from the chromosomal translocation t(11;14)(q13.3;q32.3), which juxtaposes the CCND1 gene adjacent to the IGH gene. This rearrangement leads to the constitutive overexpression of CCND1, a cyclin D1 protein that plays a pivotal role in cell cycle regulation. The CCND1/IGH fusion is a key genetic hallmark found in approximately 95% of patients diagnosed with mantle cell lymphomas (MCL), a subtype of low-grade peripheral B-cell neoplasms.
In addition to its prominence in MCL, the CCND1/IGH fusion has also been identified in other lymphoproliferative disorders (LPDs), including B-prolymphocytic leukemia (BLL). Moreover, it can occur, albeit less frequently, in conditions such as plasma cell myeloma and B-cell chronic lymphocytic leukemia (CLL).
Clinical Relevance: The detection of the CCND1/IGH fusion is critical for diagnosing MCL and guiding treatment decisions. Understanding the presence of this genetic alteration can provide valuable insights into disease prognosis and therapeutic options. Targeting the pathways influenced by CCND1 overexpression may open new avenues for effective treatments in patients displaying this genetic feature.
Our CCND1/IGH Full Fusion FISH Probe is an essential tool for researchers focused on elucidating the role of this fusion in lymphoproliferative disorders and advancing precision medicine strategies in oncology.
The CCND1/IGH fusion results from the chromosomal translocation t(11;14)(q13.3;q32.3), which juxtaposes the CCND1 gene adjacent to the IGH gene. This rearrangement leads to the constitutive overexpression of CCND1, a cyclin D1 protein that plays a pivotal role in cell cycle regulation. The CCND1/IGH fusion is a key genetic hallmark found in approximately 95% of patients diagnosed with mantle cell lymphomas (MCL), a subtype of low-grade peripheral B-cell neoplasms.
In addition to its prominence in MCL, the CCND1/IGH fusion has also been identified in other lymphoproliferative disorders (LPDs), including B-prolymphocytic leukemia (BLL). Moreover, it can occur, albeit less frequently, in conditions such as plasma cell myeloma and B-cell chronic lymphocytic leukemia (CLL).
Clinical Relevance: The detection of the CCND1/IGH fusion is critical for diagnosing MCL and guiding treatment decisions. Understanding the presence of this genetic alteration can provide valuable insights into disease prognosis and therapeutic options. Targeting the pathways influenced by CCND1 overexpression may open new avenues for effective treatments in patients displaying this genetic feature.
Our CCND1/IGH Full Fusion FISH Probe is an essential tool for researchers focused on elucidating the role of this fusion in lymphoproliferative disorders and advancing precision medicine strategies in oncology.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
11q13.3/ 14q32.33
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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