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CCND1 FISH Probe
- Specification
Cat.No.
FONC-126
Description
CCND1 FISH Probe is specifically designed to detect amplifications and deletions of the CCND1 gene. This probe is equipped with vibrant orange labeling for enhanced visibility, and we offer customization options to meet your specific research requirements.
Cyclin D1 (CCND1) is a critical regulator of the cell cycle, facilitating the transition from the G1 phase to the S phase in collaboration with its binding partners, CDK4 and CDK6. This process occurs through the phosphorylation and subsequent inactivation of the retinoblastoma protein (pRb), a key tumor suppressor. First identified in 1991, CCND1 has gained importance in cancer research due to its amplification in approximately 9-30% of breast cancer cases. It is also frequently overexpressed in a variety of malignancies, including melanoma, mantle cell lymphoma, glioma, and cancers of the endometrium, bladder, brain, esophagus, and colorectal region.
Clinical Relevance: Identification of CCND1 amplifications and deletions is crucial for understanding the molecular mechanisms underlying these cancers. Aberrant expression of CCND1 contributes to uncontrolled cell proliferation and has significant implications for tumor progression and treatment response. Targeting the cyclin D1 pathway may provide therapeutic strategies in cancers where this regulator is aberrantly expressed.
Cyclin D1 (CCND1) is a critical regulator of the cell cycle, facilitating the transition from the G1 phase to the S phase in collaboration with its binding partners, CDK4 and CDK6. This process occurs through the phosphorylation and subsequent inactivation of the retinoblastoma protein (pRb), a key tumor suppressor. First identified in 1991, CCND1 has gained importance in cancer research due to its amplification in approximately 9-30% of breast cancer cases. It is also frequently overexpressed in a variety of malignancies, including melanoma, mantle cell lymphoma, glioma, and cancers of the endometrium, bladder, brain, esophagus, and colorectal region.
Clinical Relevance: Identification of CCND1 amplifications and deletions is crucial for understanding the molecular mechanisms underlying these cancers. Aberrant expression of CCND1 contributes to uncontrolled cell proliferation and has significant implications for tumor progression and treatment response. Targeting the cyclin D1 pathway may provide therapeutic strategies in cancers where this regulator is aberrantly expressed.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
11q13.3
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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