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BRD4 FISH Probe
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Cat.No.
FONC-145
Description
BRD4 FISH Probe is expertly developed to detect and confirm aberrations of the BRD4 gene, a critical player in various oncogenic processes.
The BRD4 (Bromodomain-containing protein 4) gene is a member of the BET (bromodomain and extraterminal) protein family and is involved in regulating gene expression through its interaction with acetylated histones. Aberrations in BRD4 have been implicated in several malignancies, including acute myeloid leukemia (AML) and various solid tumors. The gene plays a significant role in the transcriptional regulation of oncogenes, making it a key target for therapeutic intervention.
Clinical Relevance: Detecting BRD4 aberrations is essential for understanding the molecular mechanisms underlying tumorigenesis and for identifying potential therapeutic targets. The presence of BRD4 fusions or amplifications can indicate a more aggressive disease phenotype and may influence treatment decisions. Targeted therapies, such as BET inhibitors, have shown promise in preclinical and clinical settings, particularly in cancers with BRD4 dysregulation.
Our custom BRD4 FISH Probe is an invaluable tool for researchers dedicated to advancing the understanding of BRD4 in cancer biology.
The BRD4 (Bromodomain-containing protein 4) gene is a member of the BET (bromodomain and extraterminal) protein family and is involved in regulating gene expression through its interaction with acetylated histones. Aberrations in BRD4 have been implicated in several malignancies, including acute myeloid leukemia (AML) and various solid tumors. The gene plays a significant role in the transcriptional regulation of oncogenes, making it a key target for therapeutic intervention.
Clinical Relevance: Detecting BRD4 aberrations is essential for understanding the molecular mechanisms underlying tumorigenesis and for identifying potential therapeutic targets. The presence of BRD4 fusions or amplifications can indicate a more aggressive disease phenotype and may influence treatment decisions. Targeted therapies, such as BET inhibitors, have shown promise in preclinical and clinical settings, particularly in cancers with BRD4 dysregulation.
Our custom BRD4 FISH Probe is an invaluable tool for researchers dedicated to advancing the understanding of BRD4 in cancer biology.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Specificity
Human
Locus
19p13.12
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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