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ABL2 Break Apart FISH Probe
- Specification
Cat.No.
FONC-151
Description
ABL2 Break Apart FISH Probe is specifically designed to detect translocations of the ABL2 gene, providing critical insights into the genetic alterations associated with various hematological malignancies. This probe is labeled in vibrant orange and green for optimal visualization, and customization options are available to meet your specific research needs.
ABL2 is a member of the Abelson nonreceptor tyrosine kinase family, closely related to ABL1. It plays a vital role in regulating actin rearrangement through the phosphorylation of key cytoskeleton-remodeling proteins, including MYH10, CTTN (cortactin), and TUBB (tubulin beta). These functions are essential for maintaining cellular structure and motility, making ABL2 an important player in various cellular processes.
Rearrangements of the ABL2 gene have been identified in several types of leukemia, often resulting in fusions with the ETV6 gene. These fusions can disrupt normal cellular signaling pathways and contribute to the pathogenesis of hematological malignancies. The presence of ABL2-ETV6 fusions has been associated with specific leukemia subtypes, highlighting the importance of monitoring ABL2 alterations in clinical settings.
Utilizing our ABL2 Break Apart FISH Probe allows researchers to enhance their understanding of ABL2-related genetic changes, facilitating accurate diagnosis and informed treatment strategies for patients with leukemia.
ABL2 is a member of the Abelson nonreceptor tyrosine kinase family, closely related to ABL1. It plays a vital role in regulating actin rearrangement through the phosphorylation of key cytoskeleton-remodeling proteins, including MYH10, CTTN (cortactin), and TUBB (tubulin beta). These functions are essential for maintaining cellular structure and motility, making ABL2 an important player in various cellular processes.
Rearrangements of the ABL2 gene have been identified in several types of leukemia, often resulting in fusions with the ETV6 gene. These fusions can disrupt normal cellular signaling pathways and contribute to the pathogenesis of hematological malignancies. The presence of ABL2-ETV6 fusions has been associated with specific leukemia subtypes, highlighting the importance of monitoring ABL2 alterations in clinical settings.
Utilizing our ABL2 Break Apart FISH Probe allows researchers to enhance their understanding of ABL2-related genetic changes, facilitating accurate diagnosis and informed treatment strategies for patients with leukemia.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
1q25.2
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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