Featured Products
- EUB338 Probe
- WCP 1 FISH Probe
- WCP 2 FISH Probe
- WCP 5 FISH Probe
- WCP 7 FISH Probe
- WCP 11 FISH Probe
- WCP 17 FISH Probe
- WCP Y FISH Probe
- Mouse Chromosome 2 Point Probe
- Mouse Chromosome 4 Point Probe
- Mouse Chromosome 5 Point Probe
- Mouse Chromosome 9 Point Probe
- Mouse Chromosome 11 Point Probe
- Mouse Chromosome 12 Point Probe
- Mouse Chromosome 14 Point Probe
- Mouse Chromosome 15 Point Probe
- Mouse Chromosome 16 Point Probe
- Mouse Chromosome 18 Point Probe
Our Promise to You
Guaranteed product quality, expert customer support
ABL1 Break Apart FISH Probe
- Specification
Cat.No.
FONC-150
Description
ABL1 Break Apart FISH Probe is specifically designed to detect translocations of the ABL1 gene, providing essential insights into the genetic landscape of hematological malignancies. This probe is labeled in bright green and orange for optimal visualization, and customization options are available to meet your specific research needs.
The ABL1 protein plays a critical role in regulating various cellular processes, including actin binding and remodeling, cell motility, adhesion, receptor endocytosis, and autophagy. It is also involved in DNA damage response, aiding in checkpoint repair after moderate damage and triggering apoptosis following severe damage.
ABL1 is most renowned for its fusion with the BCR gene, resulting in the BCR-ABL1 fusion gene, commonly referred to as the Philadelphia Chromosome, which is a hallmark of chronic myeloid leukemia (CML). However, ABL1 can also form fusions with several other partner genes, expanding its relevance in various leukemias. Notable fusions include:
ETV6-ABL1 in acute lymphoblastic leukemia (ALL), myeloproliferative neoplasms (MPN), and Ph-negative CML
RCSD1-ABL1, SEPQ-ABL1, and ZMIZ1-ABL1 in B-cell ALL
NUP214-ABL1 and EML1-ABL1 in T-cell ALL
These gene fusions typically result from the joining of the 5’ sequences of the partner gene with the 3’ sequences of ABL1. While many ABL1 fusion genes are associated with specific leukemia subtypes, both BCR-ABL1 and ETV6-ABL1 have been identified across multiple disease phenotypes. Research suggests that such non-specific fusions may arise in hematopoietic pluripotent or committed stem cells, leading to diverse leukemia presentations.
Utilizing our ABL1 Break Apart FISH Probe allows researchers to enhance their understanding of these complex genetic alterations, thereby facilitating accurate diagnosis and informed treatment options for affected patients.
The ABL1 protein plays a critical role in regulating various cellular processes, including actin binding and remodeling, cell motility, adhesion, receptor endocytosis, and autophagy. It is also involved in DNA damage response, aiding in checkpoint repair after moderate damage and triggering apoptosis following severe damage.
ABL1 is most renowned for its fusion with the BCR gene, resulting in the BCR-ABL1 fusion gene, commonly referred to as the Philadelphia Chromosome, which is a hallmark of chronic myeloid leukemia (CML). However, ABL1 can also form fusions with several other partner genes, expanding its relevance in various leukemias. Notable fusions include:
ETV6-ABL1 in acute lymphoblastic leukemia (ALL), myeloproliferative neoplasms (MPN), and Ph-negative CML
RCSD1-ABL1, SEPQ-ABL1, and ZMIZ1-ABL1 in B-cell ALL
NUP214-ABL1 and EML1-ABL1 in T-cell ALL
These gene fusions typically result from the joining of the 5’ sequences of the partner gene with the 3’ sequences of ABL1. While many ABL1 fusion genes are associated with specific leukemia subtypes, both BCR-ABL1 and ETV6-ABL1 have been identified across multiple disease phenotypes. Research suggests that such non-specific fusions may arise in hematopoietic pluripotent or committed stem cells, leading to diverse leukemia presentations.
Utilizing our ABL1 Break Apart FISH Probe allows researchers to enhance their understanding of these complex genetic alterations, thereby facilitating accurate diagnosis and informed treatment options for affected patients.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
9q34.11-q34.13
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
- Q & A
- Customer Review
Ask a Question
Write your own review
ONLINE INQUIRY
