SS19 Break Probe

Specification

Cat.No.

FONC-110

Description

Chromosomal rearrangements involving the SS18 gene located in the breakpoint region of chromsome 18q11.2 are common among synovial sarcoma soft tissue tumors. Several studies have indicated that the t(X;18)(p11.2;q11.2) translocation arises exclusively in synovial sarcoma (SS). Hybridization with the SS18 Dual Color, Break Apart Rearrangement Probe will identify a chromosomal rearrangement at the SS18 gene but not a specific gene-fusion partner. SS18 gene break-apart probes are a reliable diagnostic tool to identify SYT disruption in synovial sarcomas. In a study using 134 paraffin-embedded tumors, in which SS was the favored diagnosis, the LSI SS18 (18q11.2) Dual Color, Break Apart Rearrangement Probe identified 86% of positive cases. The conclusion from this study is that the combination of the FISH and RT-PCR approach is a powerful aid to diagnosing SS, giving at least 96% sensitivity and 100% specificity. However, using the SS18 (18q11.2) Dual Color, Break Apart Rearrangement Probe in a tissue microarray assay, FISH has been favored as the method of choice because of its versatile application to tissues with varying fixation conditions. FISH allows easier detection of a true positive result and permits a direct correlation of the translocation event with the morphology on paraffin-embedded specimen.

Size

20 Tests

Label

Red/Green

Locus

18q11.2

Specificity

Human

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

For research use only. Not for any other purpose.

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