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PTEN/CEP 11 Probe
- Specification
Cat.No.
FONC-101
Description
The gene for the phosphatase and tensin homolog (PTEN) on chromosome 10q23 is mutated in a wide range of human cancers with comparable frequency to the gene for p53. The PTEN tumor suppressor gene is mutated in multiple cancers that undergo 10q loss. The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphoinositol-3-kinase/Akt pathway. Allelic loss of chromosome 10q is one of the most common events in gliomas.
The PTEN/CEP 10 Probes performed successfully in several cytogenetic studies to detect losses of the PTEN gene. Evaluation of this probe set in a study using diffusely infiltrating astrocytoma samples correlated significantly with histological grade. The clinical findings emphasized the utility of combining histological interpretation and molecular testing. Successfully used these Probes for other relevant markers (EGFR, CDKN2A, 1p/19q) to obtain clinically useful information for 114 morphologically ambiguous high-grade gliomas composed small cells.
The PTEN/CEP 10 Probes performed successfully in several cytogenetic studies to detect losses of the PTEN gene. Evaluation of this probe set in a study using diffusely infiltrating astrocytoma samples correlated significantly with histological grade. The clinical findings emphasized the utility of combining histological interpretation and molecular testing. Successfully used these Probes for other relevant markers (EGFR, CDKN2A, 1p/19q) to obtain clinically useful information for 114 morphologically ambiguous high-grade gliomas composed small cells.
Size
20 Tests
Label
Red/Green
Locus
10p11.1-q11.1 Alpha Satellite DNA/10q23
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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