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PML/RARA Dual Color Single Fusion Probe
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Cat.No.
FHPC-088
Description
The PML/RARA Dual Color Single Fusion Probe is intended to detect the t(15;17)(q22;q21.1) reciprocal translocation involving the PML and RARA gene regions.
The vast majority of cases of acute promyelocytic leukemia (APL) have a t(15;17)(q22;q21.1) translocation which fuses the promyelocytic leukemia gene (PML) on chromosome 15q22-q24 to the retinoic acid receptor alpha gene. The PML/RARA fusion is associated with a good response to all-trans retinoic acid therapy.
This Probe was used in a study of 260 acute myeloid leukemia sampless and detected 11 positive samples. In the same study, conventional banding analysis resulted in only 7 positive results due to cytogenetic failure and one case of a cryptic translocation.
The vast majority of cases of acute promyelocytic leukemia (APL) have a t(15;17)(q22;q21.1) translocation which fuses the promyelocytic leukemia gene (PML) on chromosome 15q22-q24 to the retinoic acid receptor alpha gene. The PML/RARA fusion is associated with a good response to all-trans retinoic acid therapy.
This Probe was used in a study of 260 acute myeloid leukemia sampless and detected 11 positive samples. In the same study, conventional banding analysis resulted in only 7 positive results due to cytogenetic failure and one case of a cryptic translocation.
Size
20 Tests
Label
Red/Green
Specificity
Human
Locus
17q21/15q22
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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