PML/RARA Dual Color, Dual Fusion Translocation Probe

Cat.No.

FHPC-089

Description

The reciprocal and balanced t(15;17), involving the PML (promyelocytic leukemia) gene on chromosome 15q22 and the RARA (retinoic acid receptor alpha) gene on chromosome 17q12.1 is a characteristic molecular feature of certain types of leukemia. Two gene fusion products result from this translocation, each of which encodes a functional chimeric protein: PML/RARA and RARA/PML. The breakpoints in the 15q22 region of chromosome 15 occur within a 13 kb region of the PML gene that contains three breakpoint cluster regions (bcr): bcr 3 extends from intron 3 through the 5' end of intron 4, bcr 2 extends from exon 5 to exon 6, and bcr 1 extends from intron 6 into exon 7. Break frequency is highest in bcr 1, followed by bcr 3 and bcr 2. The breakpoints on chromosome 17 occur within the approximately 17 kb intron 2 of the RARA gene.

Size

20 Tests

Label

Red/Green

Specificity

Human

Locus

15q22/17q21.1

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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