IGH/FGFR3 Translocation, Dual Fusion Probe

Cat.No.

FHPC-064

Description

The t(4;14) (p16.3;q32.3) translocation is found in some myeloma and results in the deregulation of at least two genes. These are MMSET (Multiple Myeloma SET domain containing protein also known as WHSC1) and FGFR3 (fibroblast growth factor receptor 3) with the formation of a fusion product between MMSET and the immunoglobulin heavy chain (IGH) locus and overexpression of FGFR3. It has been suggested that FGFR3 expression is switched on by close proximity to the strong enhancer elements in the immunoglobulin heavy chain.

Size

5 Tests, 10 Tests

Label

Red/Green

Specificity

Human

Locus

4p16.3/14q32.3

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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