GRANTA-452

Cat.No.: CSC-C0691

Species: Human

Source: B cell leukemia

Morphology: round cells growing singly in suspension

Culture Properties: suspension

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Cat.No.

CSC-C0691

Description

Derived from a case of B cell acute lymphoblastic leukemia (B-ALL) following transformation from follicular B cell Non-Hodgkin lymphoma (B-NHL); described to carry a t(2;9) (p1;p13) and a t(9;14;18) (p13;q32;q21), to exhibit a biallelic deletion of CDKN2A as well as a BCL2 MBR rearrangement

Species

Human

Source

B cell leukemia

Recommended Medium

90% RPMI-1640 + 10% h.i. FBS

Culture Properties

suspension

Morphology

round cells growing singly in suspension

Karyotype

Human hyperdiploid karyotype with 5% polyploidy; 49(46-50)<2n>XXY, +X, +7, +11, der(1)t(1;7)(p36;p15), der(2)t(2;4)(p21;p15.2), der(3)t(1;3)(p26;q11), der(4)t(4;6)(p11;q22), del(6)(q13), trp(8)(q22q24), t(8;22)(q24;q11), der(9)t(2;9)(p13;p15.2), der(9)t(9

Quality Control

Mycoplasma: negative in microbiological culture, PCR assays
Immunology: CD3 -, CD10 +, CD13 -, CD19 +, CD20 -, CD34 -, CD37 +, CD38 +, cyCD79a +, CD80 +, HLA-DR +, sm/cyIgG +, sm/cyIgM -, sm/cykappa -, sm/cylambda +
Viruses: PCR: EBV -, HBV -, HCV -, HIV

Storage and Shipping

Frozen with 70% medium, 20% FBS, 10% DMSO at about 10 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

Can tumors revert to normal cells?

The ability of a cancer cell to escape malignancy' and return to a normal state sounds like the work of Houdini: seemingly impossible. But like Houdini's daring feats, tumor reversion-when malignant cells regain control of their growth and simply stop behaving like cancer cells-is a very real thing.

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