FUS Break Apart FISH Probe Kit

FONC-059

Chromosomal rearrangements involving the FUS gene located on chromosome 16p11 have been observed in many tumor types including several soft tissue sarcomas (STS). Different types of STS are characterized by specific chromosomal translocations including t(12;16)(q13;p11) FUS-DDIT3 (Myxoid liposarcoma), t(16;21)(p11;q22) FUS-ERG (Acute myeloid leukemia), t(12;16)(q13;p11) FUS-ATF1 (Angiomatoid-fibrous histiocytoma) and t(7;16)(q32-34;p11) FUS-CREB3L2 (Low grade fibromyxoid sarcoma). The resulting chimeric fusion proteins are mainly transactivators exerting deregulation of differentiation control on the tumor-target cell.1,2 Hybridization with the FUS (16p11) Dual Color, Break Apart Rearrangement Probe will identify a chromosomal rearrangement in the FUS gene region but not a specific gene-fusion partner. FUS FISH-probes were successfully used to confirm diagnosis of different sarcomas as demonstrated by several studies. This Probe detected rearrangement of the FUS gene in 7/10 formalin-fixed, paraffin-embedded tissues from low-grade fibromyxoid sarcomas. In another study the FUS Dual Color, Break Apart Rearrangement Probe was used to detect rearrangement of the FUS gene in a rare case of Ewing bone sarcoma bearing a variant chromosomal translocation t(2;16)(q35;p11) resulting in a FUS-FEV fusion gene.

20 Tests

Red/Green

Human

16p11

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade

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