FOXO2 Break Probe Kit

FONC-058

Chromosomal rearrangements involving the FOXO1 gene on chromosome 13q14 are associated with alveolar rhabdomyosarcoma (ARMS). Identification of RMS is a diagnostic dilemma for pathologists, requiring a significant amount of rule out testing for this and other soft-tissue cancers. ARMS is characterized by two consistent chromosomal translocations, the common t(2;13)(q35.2;q14) and the variant t(1;13)(p36;q14) resulting in the formation of PAX3-FOXO1 and PAX7-FOXO1fusion genes respectively (~80% of cases of ARMS). Hybridization with the Vysis LSI FOXO1 (13q14) Dual Color, Break Apart Rearrangement Probe will identify a chromosomal rearrangement at the FOXO1 gene but not a specific gene-fusion partner. This Probe consists of a mixture of two FISH DNA probes. The first probe, a 720 kb probe labeled in SpectrumGreen lies proximal to the FOXO1 gene. The second probe labeled in SpectrumOrange extends distally from the FOXO1 gene and is approximately 650 kb in length.

20 Tests

Red/Green

Human

13q14

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade

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