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CEP 12 Probe
- Specification
Cat.No.
FHPC-027
Description
CEP 12 Probe is a SpectrumOrange labeled probe specific for the alpha satellite (centromeric) region, 12p11.1-q11.
The CEP 12 Probe may be used as an adjunct to standard karotyping to identify and enumerate chromosome 12 in nuclei of cells obtained from peripheral blood lymphocytes with B-cell chronic lymphocytic leukemia (B-CLL). In multi-site l trials, the CEP 12 analysis of interphase nuclei was 100% sensitive and 91% specific as compared to traditional cytogenetic analysis when adequate metaphase preparations could be produced. Results are available within 3 hours or less. Trisomy 12 is the most commonly reported chromosome aberration in CLL. Chromosomal aberrations, determined by cytogenetic analysis are present in up to 55% of all B-CLL cases.
The CEP 12 Probe may be used as an adjunct to standard karotyping to identify and enumerate chromosome 12 in nuclei of cells obtained from peripheral blood lymphocytes with B-cell chronic lymphocytic leukemia (B-CLL). In multi-site l trials, the CEP 12 analysis of interphase nuclei was 100% sensitive and 91% specific as compared to traditional cytogenetic analysis when adequate metaphase preparations could be produced. Results are available within 3 hours or less. Trisomy 12 is the most commonly reported chromosome aberration in CLL. Chromosomal aberrations, determined by cytogenetic analysis are present in up to 55% of all B-CLL cases.
Size
20 Tests
Label
Red/Green
Specificity
Human
Locus
12p11.1-q11 Alpha Satellite DNA
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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