CCND1/CEP 11 Probe | Creative Bioarray

Cat.No.

FONC-025

Description

CCND1/CEP 11 FISH Probe Kit to detect CCND1 amplification in breast cancer samples. Al-Karaya et al. analyzed a tissue microarray of 2197 breast cancer samples using the probe kit and found CCND1 amplification in 20.1% of cases. CCND1 amplification was associated with high tumor grade and a tendency toward shortened survival. Jirstrom et al. analyzed a tissue microarray of 500 breast cancer specimens treated and not treated with adjuvant tamoxifen. The study found CCND1 amplification to be agonistic to tamoxifen with a significantly higher risk of recurrence.
The CCND1/CEP11 Probe have been applied to cancers other than breast cancer. For example, Katz et al. found elevated CCND1 copy number to be sensitive indicator of mantle cell lymphoma, and could distinguish mantle cell lymphoma from most other B-cell non Hodgkins lymphoma specimens.

Size

10 Tests

Label

Red/Green

Locus

11q13/SE 11

Specificity

Human

Usage

For Research Use Only. Not for use in diagnostic procedures.

Storage

Store at minus 20 centigrade

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

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