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6q21/MYB FISH Probe
- Specification
Cat.No.
FONC-149
Description
6q21/MYB FISH Probe is specifically designed to detect deletions in the 6q21 and 6q23.3 regions, which include the critical genes SEC63 and MYB. This probe is labeled in vibrant orange and green for optimal visualization, and we offer customization options to meet your specific research needs.
Chromosome 6q deletions are frequently observed in a variety of cancers and lymphoproliferative disorders, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, diffuse large B-cell lymphoma, and follicular lymphoma. Aberrations in these regions are of significant clinical importance, as they can play a role in disease progression and patient prognosis.
The MYB gene is a transcriptional regulator that plays a central role in directing hematopoiesis. It is recognized as a well-established oncogene in several lymphomas and leukemias, providing critical insights into the mechanisms of tumorigenesis. Loss of MYB function can disrupt normal cellular differentiation and proliferation, contributing to the development of malignancies.
In addition, the SEC63 gene regulates the transport of precursor polypeptides across the endoplasmic reticulum and has been implicated in various human cancers. Beyond its involvement in oncogenesis, SEC63 has also been associated with the pathogenesis of polycystic liver disease, further emphasizing its biological importance.
Detecting deletions in the 6q21 and 6q23.3 regions using our 6q21/MYB FISH Probe is essential for understanding the molecular landscape of associated malignancies. This probe aids in identifying genetic alterations that may impact patient management and therapeutic strategies.
Our 6q21/MYB FISH Probe is designed to meet the diverse needs of your research applications, facilitating the exploration of MYB and SEC63's roles in cancer biology and improving patient care.
Chromosome 6q deletions are frequently observed in a variety of cancers and lymphoproliferative disorders, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, diffuse large B-cell lymphoma, and follicular lymphoma. Aberrations in these regions are of significant clinical importance, as they can play a role in disease progression and patient prognosis.
The MYB gene is a transcriptional regulator that plays a central role in directing hematopoiesis. It is recognized as a well-established oncogene in several lymphomas and leukemias, providing critical insights into the mechanisms of tumorigenesis. Loss of MYB function can disrupt normal cellular differentiation and proliferation, contributing to the development of malignancies.
In addition, the SEC63 gene regulates the transport of precursor polypeptides across the endoplasmic reticulum and has been implicated in various human cancers. Beyond its involvement in oncogenesis, SEC63 has also been associated with the pathogenesis of polycystic liver disease, further emphasizing its biological importance.
Detecting deletions in the 6q21 and 6q23.3 regions using our 6q21/MYB FISH Probe is essential for understanding the molecular landscape of associated malignancies. This probe aids in identifying genetic alterations that may impact patient management and therapeutic strategies.
Our 6q21/MYB FISH Probe is designed to meet the diverse needs of your research applications, facilitating the exploration of MYB and SEC63's roles in cancer biology and improving patient care.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
6q21/6q23.3
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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