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- Alzheimer's Disease Modeling and Assays
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Drosophila Models
Drosophila (D. melanogaster) has gradually become an important tool for the study of Alzheimer's disease due to their short life span, along with the increased availability of techniques and tools which enabled the manipulation of certain gene expression. In addition, well characterized neuroanatomy and phenotypes related to Alzheimer's disease have better explained in Drosophila. Orthologues of the genes related to AD, such as APPL, have been identified in Drosophila and more importantly, the proteolytic activity of γ-secretase was found in both Drosophila and humans. However, there is no formation of Aβ peptides due to the lack of β-secretase activity and sequence differences between APPL and APP. Research has shown that expressing human APP and human β-secretase in fly nervous system produced Aβ deposition and substantially shortened the life span of them. Moreover, the neural toxicity could be revealed by the level of Aβ secreted in Drosophila. In addition, a tauopathy model in Drosophila has been established which can be used in genetic screens for modifiers of tau pathology with obvious pathological phenotypes. Creative Bioarray specializes in providing customized pharmacodynamic research services to help customers assess the efficacy of drug candidates and study the associated pathological mechanisms through Drosophila models.
Figure. 1. Drosophila
Creative Bioarray provides you with Drosophila models including but not limited to:
- Drosophila Aβ42 model
- Drosophila ttau-hyperphosphorylation model
Our Capabilities
- We use Drosophila models to screen for drugs targeting AD.
- We provide comprehensive memory tests on Drosophila models and the drug screening.
- We evaluate various biomarkers through WB, IHC, sequencing, etc.
Assays available
- Memory test
- Locomotion test
- Life span assay
- Brain sectioning for pathology
- Stress tests
- Gene profilingGene profiling
Creative Bioarray has years of experience in establishing Drosophila models. We also provide adjacent services to meet your specific needs. We are confident to help you to overcome possible upcoming challenges in your research. With our help, we wish to facilitate your study with high efficiency.
Study examples
Figure. 2. Climbing ability of in Aβ-flies (transgenic Drosophila expressing human amyloid beta-42 ) and control flies for a period of 33 days. The values are the mean of five assays. (*Significant at p<0.05 compared to Aβ-flies (AD flies).
Figure. 3. Effect of kaempferol on the climbing ability. [K1=10 µM; K2= 20 µM; K3 = 30 µM; K4= 40 µM; C= control; AD = Aβ-flies; Donepezil hydrochloride (DH)=10-3 M]. The flies were allowed to feed on the diet supplemented with kaempferol for 30 days and then assayed for climbing ability. The values are the mean of 5 assays. [asignificant at p<0.05 compared to control; bsignificant at p<0.05 compared to Aβ-flies].
Quotation and ordering
If you have any special needs or questions regarding our services, please feel free to contact us. We look forward to cooperating with you in the future.
Reference
- Beg T et al. Protective Effect of Kaempferol on the Transgenic Drosophila Model of Alzheimer’s Disease[J]. CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders), 2018, 17(6):421-429.
For research use only. Not for any other purpose.
