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Services
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Cell Services
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Cell Line Testing and Assays
- Toxicology Assay
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Stem Cell Research
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iPSC Differentiation
- Neural Stem Cells Differentiation Service from iPSC
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ISH/FISH Services
- In Situ Hybridization (ISH) & RNAscope Service
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FISH Applications
- Multicolor FISH (M-FISH) Analysis
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- Transgene Mapping (Locus Amplification & Sequencing)
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- Genetic Stability Testing (Locus Amplification & Sequencing + ddPCR)
- Clonality Analysis Service (FISH)
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In Vivo DMPK Services
- Pharmacokinetic and Toxicokinetic
- PK/PD Biomarker Analysis
- Bioavailability and Bioequivalence
- Bioanalytical Package
- Metabolite Profiling and Identification
- In Vivo Toxicity Study
- Mass Balance, Excretion and Expired Air Collection
- Administration Routes and Biofluid Sampling
- Quantitative Tissue Distribution
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- Drug Toxicity Services
Neurite Outgrowth Assay Service
The growth of neurites in human neurons is a critical event in neuronal formation, development and remodeling of synapses, response to injury, and regeneration. Measurement of neurite outgrowth can be of use in the research, screening and validation phases of the drug discovery process. In addition, a neurite outgrowth assay can also be used for the detection of toxic neuropathies.
Neurite growth is a key readout to monitor neurological function and health. Creative Bioarray has developed a range of in vitro neurite outgrowth assays that performed in a variety of cell lines or primary cell cultures to identify and characterize compounds inducing neurotoxicity, neuroprotection, neuroregeneration, or modulating neuritogenesis.
Capability of Our Neurite Outgrowth Services
- Screen for neurotoxicity
- Investigate neuroprotective treatments
- Study pathways involved in neurodegeneration
- Measure neuronal differentiation in real time
Neurite Outgrowth Endpoints
- The number of neuronal bodies
- The number of promoted neurite
- Neurite length
- The number of branch points
- The number of neurite segments
Besides, a detailed control image is generated in order to help you to visualize the parameters
Key Highlights
- Observe and quantify long-term changes in neurite length and branch points
- Perform experiments on 24- or 96-well plates without removing the plates from incubator
- Continuous measurement in a highly flexible, robust and reproducible analysis format suitable for screening and profiling
- Continuous monitoring of cytotoxicity and apoptosis in neuronal cultures
- Simultaneous measurement of neurodynamics and neuronal health
- Reduce time and expense by optimized protocols and QC validated products
If you have any special needs, please contact us. Let us know what you need and we will meet your requirements. We look forward to working with you. Thank you for choosing Creative Bioarray services!
References
- Sherman S P. et al.; High-throughput screen for compounds that modulate neurite growth of human induced pluripotent stem cell-derived neurons. Disease Models & Mechanisms, 2018, 11(2).
- Filous A R. et al.; Neurite outgrowth assay. Bio Protoc, 2016, 6(1).
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For research use only. Not for any other purpose.
