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NCOA2 Break Apart FISH Probe
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Cat.No.
FONC-122
Description
NCOA2 Break Apart FISH Probe is specifically designed to detect translocations involving the NCOA2 gene, providing critical insights into genetic alterations. This probe is available with vibrant orange and green labeling for enhanced visualization, and we offer customization options to meet your specific research needs.
NCOA2 (Nuclear Receptor Coactivator 2) is a key transcriptional coactivator that plays a significant role in the regulation of gene expression, particularly in response to steroid hormones. Abnormalities in NCOA2, including translocations, have been implicated in various malignancies, particularly in breast cancer and other solid tumors. The most common translocation involving NCOA2 is t(2;20)(q35;q13), which can lead to the formation of fusion proteins that contribute to oncogenic processes.
Clinical Relevance: The detection of NCOA2 translocations is crucial for understanding tumor biology and can aid in the diagnosis and prognosis of cancers. Identifying these genetic alterations can also inform treatment strategies, as tumors with NCOA2 involvement may respond differently to targeted therapies.
Our NCOA2 Break Apart FISH Probe is an essential tool for researchers and clinicians aiming to explore the complexities of cancer genetics and improve patient outcomes.
NCOA2 (Nuclear Receptor Coactivator 2) is a key transcriptional coactivator that plays a significant role in the regulation of gene expression, particularly in response to steroid hormones. Abnormalities in NCOA2, including translocations, have been implicated in various malignancies, particularly in breast cancer and other solid tumors. The most common translocation involving NCOA2 is t(2;20)(q35;q13), which can lead to the formation of fusion proteins that contribute to oncogenic processes.
Clinical Relevance: The detection of NCOA2 translocations is crucial for understanding tumor biology and can aid in the diagnosis and prognosis of cancers. Identifying these genetic alterations can also inform treatment strategies, as tumors with NCOA2 involvement may respond differently to targeted therapies.
Our NCOA2 Break Apart FISH Probe is an essential tool for researchers and clinicians aiming to explore the complexities of cancer genetics and improve patient outcomes.
Size
10 Tests; 20 Tests
Label
Orange/Green
Specificity
Human
Locus
8q13.3
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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