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FGFR3-IGH Full FISH Probe
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Cat.No.
FONC-146
Description
FGFR3-IGH Full Fusion Probe is specifically designed to detect fusions between the FGFR3 gene and the IGH locus. Unlike our split FGFR3-IGH probe, this full probe encompasses the entire IGH gene, providing a comprehensive solution for identifying genetic rearrangements. The probe is labeled in vibrant orange and green for optimal visualization, and we offer customization options to suit your specific research requirements.
The FGFR3 (Fibroblast Growth Factor Receptor 3) gene is essential for regulating skeletal and neuronal development, while the IGH (Immunoglobulin Heavy Chain) locus is a significant area for immunological function. Fusions involving FGFR3 and IGH have been implicated in various lymphoid malignancies, such as multiple myeloma and other hematological disorders. Identifying these fusions is critical for diagnosis, prognosis, and therapeutic strategies.
Clinical Relevance: Detecting FGFR3/IGH fusions is crucial for understanding the molecular mechanisms underlying these malignancies. The presence of such fusions can indicate a poor prognosis and a more aggressive disease course. Furthermore, identifying these alterations can help guide treatment decisions, including the use of targeted therapies that address specific genetic abnormalities.
It's important to note that the IGH gene region is characterized by high levels of cross-homology with other genomic regions. This homology can lead to diffuse probe signals, which may affect the interpretation of results. Proper validation and rigorous controls are recommended when utilizing this probe to minimize potential background noise and ensure accurate results.
Our FGFR3-IGH Full Fusion Probe is an invaluable tool for researchers focused on advancing the understanding of genetic alterations in hematological malignancies. By utilizing this probe, you can enhance your ability to detect and confirm critical fusions that may impact patient management and treatment outcomes.
The FGFR3 (Fibroblast Growth Factor Receptor 3) gene is essential for regulating skeletal and neuronal development, while the IGH (Immunoglobulin Heavy Chain) locus is a significant area for immunological function. Fusions involving FGFR3 and IGH have been implicated in various lymphoid malignancies, such as multiple myeloma and other hematological disorders. Identifying these fusions is critical for diagnosis, prognosis, and therapeutic strategies.
Clinical Relevance: Detecting FGFR3/IGH fusions is crucial for understanding the molecular mechanisms underlying these malignancies. The presence of such fusions can indicate a poor prognosis and a more aggressive disease course. Furthermore, identifying these alterations can help guide treatment decisions, including the use of targeted therapies that address specific genetic abnormalities.
It's important to note that the IGH gene region is characterized by high levels of cross-homology with other genomic regions. This homology can lead to diffuse probe signals, which may affect the interpretation of results. Proper validation and rigorous controls are recommended when utilizing this probe to minimize potential background noise and ensure accurate results.
Our FGFR3-IGH Full Fusion Probe is an invaluable tool for researchers focused on advancing the understanding of genetic alterations in hematological malignancies. By utilizing this probe, you can enhance your ability to detect and confirm critical fusions that may impact patient management and treatment outcomes.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Specificity
Human
Locus
4p16.3/14q32.33
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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