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Skin Grafts-Induced Alopecia Areata (AA) Model
Alopecia areata (AA) is a condition characterized by hair loss from some or all areas of the body. While psychological stress and illness may trigger AA in predisposed individuals, the precise cause often remains unidentified. This lack of understanding hampers the development of effective clinical therapies and preventive measures. To investigate the pathobiology of AA and assess potential treatments, a reliable animal model is essential.
Creative Bioarray is proud to offer our Skin Grafts-Induced Alopecia Areata (AA) Model, ideal for evaluating the efficacy of your test compounds. Our approach utilizes aging C3H/HeJ mice, which spontaneously exhibit AA-like hair loss. By grafting skin from AA-affected C3H/HeJ mice onto healthy C3H/HeJ mice, we successfully induce hair loss through lymphocyte-mediated inflammation. This reproducible model serves as a powerful tool for studying both the pathogenesis and clinical treatment of alopecia areata.
Our Skin Grafts-Induced Alopecia Areata (AA) Model
Available Animal
C3H/HeJ mouse
Modeling Method
Sham Group: Mice receive skin grafts from healthy C3H/HeJ mice, serving as a control.
Model & Test Compounds Groups: Mice undergo skin grafting with tissue from AA-affected C3H/HeJ mice, allowing for the study of disease progression and the efficacy of test compounds.
Endpoints
- Image of mice
- Hair loss area
- Histology analysis
- Spleen weight
- qPCR or Western blot
- Customized endpoints tailored to your specific research requirements
Quotation and Ordering
Creative Bioarray is delighted to impart our pioneering technology and profound expertise in rodent disease modeling, aimed at enhancing our clients' research endeavors and project advancements. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly.
For research use only. Not for any other purpose.
