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BCL2 FISH Probe
- Specification
Cat.No.
FONC-125
Description
BCL2 FISH Probe is expertly designed to detect amplifications and deletions of the BCL2 gene, a crucial regulator of apoptosis. This probe is available with vibrant orange labeling for clear visualization, and customization options are offered to meet your specific research requirements.
BCL2 (B-cell lymphoma 2) is an essential gene that encodes a protein responsible for inhibiting programmed cell death, thereby promoting cell survival. Dysregulation of BCL2, often through chromosomal rearrangements, amplifications, or deletions, is commonly associated with various hematological malignancies, particularly follicular lymphoma and other B-cell lymphomas. The most notable alteration is the t(14;18) translocation, which leads to the overexpression of BCL2 and contributes to oncogenesis.
Clinical Relevance: Detecting BCL2 amplifications and deletions is vital for understanding the pathogenesis of B-cell malignancies. Identifying these genetic alterations can provide insights into disease prognosis and help guide treatment strategies, including the use of BCL2 inhibitors, which have shown promise in targeting BCL2-overexpressing tumors.
BCL2 (B-cell lymphoma 2) is an essential gene that encodes a protein responsible for inhibiting programmed cell death, thereby promoting cell survival. Dysregulation of BCL2, often through chromosomal rearrangements, amplifications, or deletions, is commonly associated with various hematological malignancies, particularly follicular lymphoma and other B-cell lymphomas. The most notable alteration is the t(14;18) translocation, which leads to the overexpression of BCL2 and contributes to oncogenesis.
Clinical Relevance: Detecting BCL2 amplifications and deletions is vital for understanding the pathogenesis of B-cell malignancies. Identifying these genetic alterations can provide insights into disease prognosis and help guide treatment strategies, including the use of BCL2 inhibitors, which have shown promise in targeting BCL2-overexpressing tumors.
Size
10 Tests; 20 Tests
Label
Orange/Green/Aqua
Locus
18q21.33
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.
Storage
Store at minus 20 centigrade in the dark
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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