3D-Based Drug Discovery Services

2D cell cultures have been widely used in the cell-based drug discovery tests and have served as a simple and cost-effective tool to quickly screening drug candidates instead of high-cost in vivo animal tests. However, due to its limitations of not being able to realistically mimic in vivo cell behaviors, 2D cell culture-based tests are unable to rule out compounds that lack clinical efficacy or cause unacceptable toxicity, and consequently lead to more drug failure in the following more expensive phases of drug. Meanwhile, 3D cell cultures have been shown to exhibit more in-vivo-like behaviors and responses compared to 2D cultures, with cell-cell and cell-extracellular matrix (ECM) interactions as well as nutrient and drug spatial gradient that resemble in vivo environments. Drug tests using 3D cell cultures are capable of providing more reliable and applicable results, enabling better estimate of in vivo responses and lower overall cost by reducing future drug failure incidents.

In response to the increasing need for tests using 3D cell culture systems in the drug discovery field, Creative Bioarray has developed a panel of 3D-based drug discovery services to provide more predictable data to in vivo tests. Our well-developed 3D-based drug discovery services include:

• High content image service: evaluates drug efficacy and toxicity by simultaneously measuring multiple phenotypical parameters using state-of-art automated fluorescence imaging techniques.
• ATP content assay: gives out IC50 and minimum effective concentration (MEC) as well as general toxicity information of a compound using our 3D cell culture models.
• 3D hepatotoxicity service: provides reliable multi-parametric hepatotoxicity data using 3D hepatocyte spheroids from several species.
• 3D cardiovascular toxicity service: Capable of providing several physiologic model systems of 3D culture made by cell lines, human iPS cells and ES cells for you to choose.

Creative Bioarray 3D-based drug discovery service advantages

• Custom generation of 3D microtissues made with cells from our comprehensive human and animal cell bank or sending your own cells.
• Plan/design your project and set your goals and measurement parameters with our expertise.
• Time- and labor- efficient tests will cover most evaluation aspects.
• Professional after-sale services to follow up and solve the potential problems.

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