SUP-T11

Cat.No.: CSC-C0605

Species: Human

Source: T cell leukemia

Morphology: small, polymorph cells growing singly in suspension

Culture Properties: suspension

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Cat.No.

CSC-C0605

Description

Derived from the bone marrow of a 74-year-old man with T-ALL at diagnosis; cell line was established in the presence of IGF-I under hypoxic conditions; cells were described to express high levels of TCL1A and TCL1B genes due to their juxtaposition from chromosome 14q32.1 to the regulatory element of the T-cell receptor C alpha/delta locus at chromosome 14q11

Species

Human

Source

T cell leukemia

Recommended Medium

90% RPMI-1640 + 10% h.i. FBS

Culture Properties

suspension

Morphology

small, polymorph cells growing singly in suspension

Karyotype

Human highly rearranged hypodiploid karyotype with 5% polyploidy; 38(36-39)<2n>XX, -Y, -10, -13, -15, -16, -17, -21, -22, del(X)(q11?q23), add(X)(q23), der(1)del(1)(p32)t(1;4)(q32;q32.2), der(1)t(1;7)(q32;q32), der(2)t(2;4)(p23;p15 or q35), der(3)t(1;3)(p

Quality Control

Mycoplasma: negative in microbiological culture, PCR assays
Immunology: CD2 +, CD3 +, CD4 -, CD5 +, CD6 +, CD7 +, CD8 -, CD13 -, CD19 -, CD20 -, CD34 -, HLA-DR -
Viruses: PCR: EBV -, HBV -, HCV -, HIV -, HTLV-I/II -, SMRV -

Storage and Shipping

Frozen with 70% medium, 20% FBS, 10% DMSO at about 5 x 10^6 cells/ampoule; ship in dry ice; store in liquid nitrogen

Citation Guidance

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.

Are there chromosomes in tumor cells?

Solid tumors often contain many structural rearrangements involving multiple chromosomes and multiple breakpoints, and frequently cells from the same tumor contain different rearranged chromosomes, indicative of ongoing chromosome structure instability (CSI).

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