BRAF Probe

FONC-023

The BRAF Probe is based on the ability of BRAF locus specific identifier (LSI) probe to identify copy number changes of 7q34 chromosomal locus, using a FISH test. BRAF is one of three serine/threonine RAF-regulated kinases that have an important role in cellular proliferation, differentiation, and programmed cell death.1 It alsoparticipates in the RAS-RAF-MEK-ERK-BRAF in promoting tumorigenesis (malignant transformation of kinase BRAFs). Mutationally activated BRAF-V600E is detected in melanoma (70%), colorectal (15%), papillary thyroid (40%), ovarian (30%), and non-small-cell lung cancers (NSCLCs) (3%). Melanoma with activating mutation of BRAF is more likely tohave copy gains at the BRAF locus.4 BRAF copy number gains have been identified in both follicular thyroid cancer and malignant melanoma, and may occur through either gene amplification or chromosome 7 polysomy. The BRAF copy number gains are expected in lung cancer, where chromosome 7 is also amplified.

20 Tests

Red/Green

Human

7q34

For Research Use Only. Not for use in diagnostic procedures.

Store at minus 20 centigrade

If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.