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BCR/ABL Plus Translocation, Dual Fusion Probe
- Specification
Cat.No.
FHPC-019
Description
The abnormality is characteristic of Chronic Myeloid Leukaemia (CML), found in around 90% of cases but represents a significant abnormality in 30% of adult and 2 to 10% of childhood Acute Lymphoblastic Leukaemia (ALL) cases.
This rearrangement is also seen in rare cases of acute myelogenous leukemia (AML). As a result of the Philadelphia translocation, t(9;22)(q34;q11), the ABL1 (Abelson) proto-oncogene and the BCR (Breakpoint Cluster Region) gene fuse, giving rise to the BCR/ABL1 hybrid or 'fusion' gene. The translocation between chromosomes 9 and 22 can be accompanied by loss of proximal sequence (ASS1/ABL1) and distal 22q found in ALL and rare cases of AML. The establishment of the atypical patterns in the BCR/ABL1 translocation may have detective implications.
This rearrangement is also seen in rare cases of acute myelogenous leukemia (AML). As a result of the Philadelphia translocation, t(9;22)(q34;q11), the ABL1 (Abelson) proto-oncogene and the BCR (Breakpoint Cluster Region) gene fuse, giving rise to the BCR/ABL1 hybrid or 'fusion' gene. The translocation between chromosomes 9 and 22 can be accompanied by loss of proximal sequence (ASS1/ABL1) and distal 22q found in ALL and rare cases of AML. The establishment of the atypical patterns in the BCR/ABL1 translocation may have detective implications.
Size
5 Tests, 10 Tests
Label
Red/Green
Locus
9q34/22q11
Specificity
Human
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
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