Featured Products
- EUB338 Probe
- WCP 1 FISH Probe
- WCP 2 FISH Probe
- WCP 5 FISH Probe
- WCP 7 FISH Probe
- WCP 11 FISH Probe
- WCP 17 FISH Probe
- WCP Y FISH Probe
- Mouse Chromosome 2 Point Probe
- Mouse Chromosome 4 Point Probe
- Mouse Chromosome 5 Point Probe
- Mouse Chromosome 9 Point Probe
- Mouse Chromosome 11 Point Probe
- Mouse Chromosome 12 Point Probe
- Mouse Chromosome 14 Point Probe
- Mouse Chromosome 15 Point Probe
- Mouse Chromosome 16 Point Probe
- Mouse Chromosome 18 Point Probe
Our Promise to You
Guaranteed product quality, expert customer support
4q12 Tri-Color Rearrangement Probe
- Specification
Cat.No.
FHPC-003
Description
The 4q12 Tri-Color Rearrangement FISH Probe is intended to detect rearrangements in chromosome 4q12 involving the FIP1L1-PDGFRA region, using FISH.
Chronic Eosinophilic Leukemia (CEL) is described by the World Health Organization (WHO) as a neoplasm in which clonal proliferation of eosinophil precursors results in prolonged eosinophilia. The chromosomal anomaly, del(4)(q12q12), results in a fusion of FIP1L1 and PDGFRA and is found in 40-60% of CEL syndromes. The Vysis LSI 4q12 Tri-Color Rearrangement Probe has been used to detect an approximately 800 kb deletion containing LNX and CHIC2 and subsequent fusion of FIP1L1 and PDGFRA. The current WHO classification system places myeloproliferative neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 into their own detective category, while CEL lacking aberrations of these and several other genes falls into the CEL, not otherwise specified
Chronic Eosinophilic Leukemia (CEL) is described by the World Health Organization (WHO) as a neoplasm in which clonal proliferation of eosinophil precursors results in prolonged eosinophilia. The chromosomal anomaly, del(4)(q12q12), results in a fusion of FIP1L1 and PDGFRA and is found in 40-60% of CEL syndromes. The Vysis LSI 4q12 Tri-Color Rearrangement Probe has been used to detect an approximately 800 kb deletion containing LNX and CHIC2 and subsequent fusion of FIP1L1 and PDGFRA. The current WHO classification system places myeloproliferative neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 into their own detective category, while CEL lacking aberrations of these and several other genes falls into the CEL, not otherwise specified
Size
20 Tests
Label
Red/Green
Specificity
Human
Locus
4q12
Usage
For Research Use Only. Not for use in diagnostic procedures.Storage
Store at minus 20 centigrade
Citation Guidance
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the PubMed ID of your paper to get a coupon.
- Q & A
- Customer Review
Ask a Question
Write your own review
ONLINE INQUIRY
